Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Nutr Cancer 2007;57(1):100-110. View abstract. Monitor your blood sugar closely. 2021 Jun 28;274:114052. 2013;140:22-30. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Animal models also suggest antitumor activity with S. barbata across a range of cancers(16)(17)(18)(19)(20). View abstract. Am J Chin Med 2006;34(2):245-261. US Food and Drug Administration (FDA). Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. View abstract. View abstract. J Nat Prod 2009;72(9):1616-1619. View abstract. View abstract. WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. Eksp Klin Farmakol 1997;60:49-51. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. However, lab tests have shown that it is a herb that can reduce inflammation and have antioxidant properties. Phytother Res 2000;14:210-2. Scutellaria Baicalensis ( Baical Skullcap ) is a plant. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Journal of medicinal food 2009;12(5):1143-8. Konig J, Seithel A, Gradhand U, Fromm MF. You, C. L., Su, P. Q., and Zhou, X. X. Biochim.Biophys Acta 2011;1813(8):1465-1474. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. 2009;86(2):79-84. Kong XT, Fang HT, Jiang GQ, et al. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. Macrophages are immune cells that are involved in your bodys inflammation response. Baikal skullcap might cause sleepiness and slowed breathing. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. View abstract. Zhang CZ, Wang SX, Zhang Y, et al. Accessed on September 1, 2021. View abstract. View abstract. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Case Reports Heptal 2016;2016:4356749. View abstract. Taking Baikal skullcap along with diabetes medications might cause blood sugar to drop too low. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Chen C, Mireles RJ, Campbell SD, et al. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. Zhong.Yao Cai. View abstract. View abstract. View abstract. View abstract. 5-24-2006;105(3):346-351. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). Onco Targets Ther 2016;9:2935-43. View abstract. View abstract. Research shows that Chinese skullcap extract is toxic to cancer cells, such as brain tumor cells, prostate cancer cells, and head and neck squamous cell carcinoma cell lines. View abstract. View abstract. View abstract. FEBS Lett. International Journal of Pharmacology 2010;6(2):81-88. View abstract. Baikal skullcap is used to treat respiratory infections, hay fever, and fever. J Ethnopharmacol 2005;98:295-300. Baicalin induces apoptosis via mitochondrial pathway as prooxidant. It might cause drowsiness. Pharmacology 2006;77(2):71-77. Planta Med 2000;66:70-1. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Jin BR, Chung KS, Kim HJ, An HJ. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. This will help them manage your care and keep you safe. View abstract. It might cause drowsiness. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. J Cell Biochem 12-15-2010;111(6):1629-1641. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Treatment of acute bronchiolitis with Chinese herbs. View abstract. Accessed Sept 30, 2016. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Przegl.Lek. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. 1999;385-6, 400-1. J Med Food 2009;12:1143-8. Planta Med 2003;69(4):300-304. However, different extraction methodologies and/or plant origins have yielded varying degrees of antitumor effects(21). Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. This might increase the side effects of some medications. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Taking Baikal skullcap with these medications might decrease how well the medication works. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Zhou J, Qu F, Yu Y, et al. Hu, J. Statements made about products have not been evaluated by the Food and Drug Administration. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. Am J Chin Med 2008;36(3):517-540. View abstract. View abstract. A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). PC-SPES (PDQ) - Health Professional Version. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. We currently have no information for BAIKAL SKULLCAP overview. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. View abstract. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Front Biosci. 10-18-2009;41(5):578-584. 2011;10(2):184-191. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. This will help them manage your care and keep you safe. Wang R.T, Zhang J.X, and Dong Y.J. It is also used for scarlet fever, headache, irritability, red eyes, flushed face, seizures, epilepsy, hysteria, nervous tension, and to relieve a bitter taste in the mouth. Kaplya, O. View abstract. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. View abstract. The total content of these 6 main flavonoids account ed for 68.5% of the extract . View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. View abstract. Clin Pharmacol Ther 2007;82:726-33. View abstract. 2004;23(8):874-878. Gabrielska, J., Oszmianski, J., Zylka, R., and Komorowska, M. Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. In Vivo 2004;18(4):497-503. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. View abstract. 2002;51(6):277-283. Nahrung 2004;48(2):123-128. View abstract. Wu, J., Hu, D., and Wang, K. X. Therefore, if you are a diabetic patient, you should stay away from such herbs. Orzechowska B, Chaber R, Wisniewska A, et al. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). Baikal skullcap might increase how quickly the liver breaks down some medications. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. View abstract. View abstract. 2007;42(10):1074-1077. This Chinese herb may slow down blood clotting, increasing the risk of bleeding and bruising in people who already have some bleeding disorders. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Shim K.S, Kim S.N, Kim M.H, and et al. View abstract. New York, NY: CRC Press LLC. Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. View abstract. Ready to start planning your care? Ready to start planning your care? [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. Acta Pharmacol Sin. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. View abstract. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. View abstract. Int J Mol Med 2004;14(4):627-632. 1-8-2007;245(1-2):269-274. Baikal skullcap might lower blood pressure. Ann Intern Med 2012;156:857-60. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. View abstract. Baikal skullcap might also cause sleepiness and drowsiness. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. View abstract. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. View abstract. Zeng H.Y and Praveen K.S. 1-8-2007;245(1-2):269-274. Avoid skin and eye contact and breathing in dust. View abstract. Afr J Tradit Complement Altern Med. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments Pharmacist's Kaplya, O. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Cancer Lett. Planta Med 2002;68(2):128-132. View abstract. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. 2006;63(2):95-96. J Ethnopharmacol. Taking Baikal skullcap might decrease how well the body gets rid of lithium. View abstract. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Phytother.Res 2009;23(10):1415-1420. WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. 1-19-2007;109(2):325-330. View abstract. Cancer Lett. 2009;48(12):1159-1169. Med Hypotheses. CNS.Neurol.Disord Drug Targets. Afr J Tradit.Complement Altern Med 2010;7(4):339-349. Baicalin also activated caspase-3, resulting in apoptosis of leukemia-derived T cells. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. View abstract. There have been reports of fever and lung inflammation in people who took Baikal skullcap. In some cases, this might change the effects and side effects of a medication. Planta Med 1997;63(2):141-145. [Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria]. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. https://herbpathy.com/Uses-and-Benefits-of-Scutellaria-Baicalensis-Cid5219, [Note: You are requested to write correct English only. View abstract. This could increase how much lithium is in the body and result in serious side effects. 2004;50(3):279-285. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). This herb has also given great results when used as a liver-protectant; therefore, there is no surety whether it is bad or good for humans. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. J Ethnopharmacol. View abstract. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. 1-29-2010;469(3):298-302. View abstract. View abstract. Vopr.Onkol. View abstract. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. BMC.Complement Altern Med 2006;6:27. Use of this Web site does not create an expressed or implied physician-patient relationship. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. View abstract. Invest New Drugs 2011;29(4):637-645. 2009;29(2):519-521. WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. 1990;36(5):602-607. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. View abstract. View abstract. Scutellaria baicalensis root: Uses, Nutr Cancer 2004;49(2):217-22. 7-28-2004;211(1):39-46. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. The pharmacology of Chinese herbs. View abstract. View abstract. Krskova, Z., Martin, J., Pec, J., and Dusek, J. View abstract. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Zhong.Yao Cai. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Huang KC. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. J Ethnopharmacol. Li BQ, Fu T, Gong WH, et al. Tan, H., Tang, Y., Zhou, X., Xiao, X., and Li, J. Of this Web site does not create an expressed or implied physician-patient.... Qin extract on Angiogenesis how well the body gets rid of lithium by diosbulbin B in mice and mechanism! Immune cells that are involved in the body and result in serious side like! Chan, F. L., Choi, H. UsToo PC-SPES surveys: review of studies and update of survey. 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